Targeting protein-protein interaction interfaces in COVID-19 drug discovery
نویسندگان
چکیده
منابع مشابه
Targeting protein-protein interactions for drug discovery.
Protein-protein interactions are associated with key activities and pathways in the cell, and in that regard are promising targets for drug discovery. However, in terms of small molecule drugs, this promise has not been realized. The physical nature of many protein-protein interaction surfaces renders them unable to support binding of small drug-like molecules. In addition, there are other uniq...
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BRD4, the most extensively studied member of the BET family, is an epigenetic regulator that localizes to DNA via binding to acetylated histones and controls the expression of therapeutically important gene regulatory networks through the recruitment of transcription factors to form mediator complexes, phosphorylating RNA polymerase II, and by its intrinsic histone acetyltransferase activity. D...
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Protein kinases (PKs) are prime targets for drug discovery in a variety of diseases, including cancer and neurodegenerative pathologies. The characterisation of the kinome of the human malaria parasite Plasmodium falciparum has revealed profound divergences, at several levels, between PKs of the parasite and those of its host. Here, the authors review the major issues and recent advances regard...
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1. Background Protein-protein interaction networks Proteins are linear chain biomolecules that are the basis of functional networks in all organisms. They include classes that regulate other proteins (e.g. kinases), classes that regulate gene expression (e.g. transcription factors), and classes that control response to disease (e.g. immunoglobulins). Aspects of their social networks have been e...
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OBJECTIVE To identify inhibitors of the essential chromosome partitioning protein ParA that are active against Mycobacterium tuberculosis. METHODS Antisense expression of the parA orthologue MSMEG_6939 was induced on the Mycobacterium smegmatis background. Screening of synthetic chemical libraries was performed to identify compounds with higher anti-mycobacterial activity in the presence of p...
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ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2021
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2021.04.003